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Agar Gel Diffusion Method for the Study of Antigenic Components of Mumps Virus

From the Department of Epidemiology and Public Health, Yale University School of Medicine, and the Yale Reference Serum Bank of the World Health Organization, New Haven, Connecticut

Abstract

A modified agar gel diffusion system for detecting mumps precipitating antibodies was investigated.

Mumps immune sera, when tested by a modified agar gel diffusion technique against concentrated soluble and viral antigens, showed a reaction only against the soluble antigen. When purified viral antigen was treated with peroxide-free ether for 15 to 30 min, a precipitating band, similar to that of the soluble antigen, was observed.

Agar gel diffusion methods may be used as a rapid tool for determination of precipitating antibodies to mumps virus, and possibly may be applied to the study of antigenically related parainfluenza viruses.