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Serologic Relationships between -Lysins of Different Species¹

From the Department of Bacteriology, Brigham Young University, Provo, Utah

Abstract

Techniques similar to the Seitz filtiation-elution procedure used to purify rabbit--lysin have been successfully employed to separate human, horse, and rat -lysins from other serum constituents. The standard purification procedure for rabbit -lysin was extended to obtain a more specific antiserum for use in studies on the serologic relationships of -lysins of different species. Neutralization studies with this antiserum have shown that qualitative serologic relationships exist between -lysins from the rat, human, horse and rabbit.

Footnotes

¹ This investigation was supported by Public Health Service Grant AI 01171 from the National Institute of Allergy and Infectious Diseases.

² Public Health Predoctoral Fellow 1-F1-GM-23, 206, National Institute of General Medical Sciences.

³ Public Health Service Career Program Award 5-K3-AI-22, 162, National Institute of Allergy and Infectious Diseases.