HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Campbell, P. A. Articles by Kind, P. D. Search for Related Content PubMed PubMed Citation Articles by Campbell, P. A. Articles by Kind, P. D.

The Adjuvant Action of Endotoxin in Thymectomized Mice¹

From the Department of Pathology, University of Colorado Medical Center, Denver, Colorado

Abstract

The adjuvant action of bacterial endotoxin on antibody production was shown to be unrelated to the effect of endotoxin on the thymus. Rates of antigen elimination and hemagglutination titers were essentially the same in adult mice which were thymectomized or sham-thymectomized and given a single injection of bovine -globulin and endotoxin. Reduction in antibody production was observed, however, when mice were thymectomized at 2 weeks of age.

Similarly, the response of adult mice to two injections of bovine -globulin and endotoxin was the same in thymectomized and sham-thymectomized mice. The antibody sedimented in a sucrose density gradient in the area of 7 S -globulin.

Footnotes

¹ This work was supported by United States Public Health Service grants GM-977-03, AM-08885-01, and AM-08434-01.

² Present address: The Rockefeller University, New York, New York.