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Immunologic Tolerance Induced by a Combination of Chloramphenicol and 6-Mercaptopurine¹

From the Medical Research Laboratory (Wilsdorf Laboratory), Clinique Universitaire de Médecine, Hôpital Cantonal, Geneva, Switzerland

Abstract

In rabbits sensitized with BSA, high doses of chloramphenicol decreased the primary response but the secondary response, initiated 40 days later, was unaffected.

6-MP at the dose of 6 mg/kg/day suppressed completely the primary response; the secondary response was either strongly decreased or suppressed. Doses of 3 and 1 mg/kg/day had similar but weaker effects on primary response, whereas secondary response was almost normal.

Combination of different doses of chloramphenicol and 6-MP resulted in stronger effects on primary response than those obtained with the same doses of each drug used separately. In addition, a fair number of animals acquired immunologic tolerance which was specific to BSA, as proved by further injections of BSA and the use of a second antigen, HGG.

No synergistic effect was however observed on the survival of skin allografts in rabbits.

Footnotes

¹ This investigation was supported by a grant from the Swiss National Foundation for Scientific Research.