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Immunochemical Studies on Dextrans

IV. Further Characterization of the Determinant Groups on Various Dextrans Involved in Their Reactions with the Homologous Human Antidextrans¹

From the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, the Neurological Institute, Presbyterian Hospital, New York, and the Department of Chemistry, Royal Holloway College, University of London, Englefield Green, Surrey, England

Abstract

A variety of oligosaccharides have been studied for their capacity to inhibit precipitation by dextrans of antidextrans with specificities directed toward chains of -1 6 linked D-glucopyranosyl units and of antidextrans with specificities involving the non -1 6 linked residues. From studies with branched oligosaccharides containing a single D-glucopyranosyl unit linked -1 3 or -1 4 to a homologue of isomaltose, additional inferences about the antidextran combining site have been drawn. Findings with 6-O-acetyl-D-glucose and various mono-methyl and deoxy-D glucoses have also aided in defining the contribution to interaction with antibody of various portions of the D-glucose molecule. Similar information has been obtained with anti-dextrans with specificities other than -1 6.

Footnotes

¹ Aided by grants from the National Science Foundation (NSF G-18727 and GB-3675), the Office of Naval Research and the General Research Support Grant of the National Institutes of Health, United States Public Health Service.

² Present address: Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.