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Serum Protein Alterations Induced by Listeria Monocytogenes Infections¹

From the Department of Microbiology, The University of Kansas, Lawrence, Kansas

Abstract

During experimental Listeria infection in mice an increase in total serum protein, serum hexose and hexose: protein ratio was observed. Paper electrophoretic studies showed an increase in - and -glycoproteins. Immunoelectrophoretic studies on serum from infected animals revealed an increase in albumin mobility, increase in 2-macroglobulin, increase in haptoglobin, increase in transferrin and conversion of 1C-globulin to 1D-globulin. Relatively little change was noted in -globulin during infection. Hyperimmunized-challenged animals showed an increase in amount and complexity of -globulin.

Footnotes

¹ This investigation was supported by Grant AI-04343 from the National Institute of Allergy and Infectious Diseases, U.S. Public Health Service, and by the University of Kansas General Research Fund.