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Hydroxylamine as an Inactivating Agent for Foot-and-Mouth Disease Virus

From the Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, United States Department of Agriculture, Greenport, Long Island, New York

Abstract

The results of a study of the inactivation of Type O, strain M 11, foot-and-mouth disease virus by treatment with varying concentrations of hydroxylamine at several temperatures are presented. The antigenicity of inactivated viral preparations was assayed in adult mice and chickens. Concentrations of 1, 0.5, 0.25 and 0.1 M hydroxylamine were effective as viral inactivators at 4, 23, and 37°C. Inactivation times varied from 15–30 min to 28 hr depending on the concentration of chemical and temperature of reaction used. The concentration of 0.25 M hydroxylamine reacted with virus at either 23 or 4°C appeared to produce the best antigenic preparation as tested by inoculation of mice and chickens.