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7S₁ and 7S₂ Antibody Response in the Mouse¹

I. Influence of Strain, Antigen and Adjuvant

From the Scripps Clinic and Research Foundation, Division of Experimental Pathology, La Jolla, California

Abstract

The qualitative aspects of the 7S antibody response in the mouse have been studied using radio-immunoelectrophoresis. The production of a fast gamma (7S₁) and/or a slow gamma (7S₂) antibody was influenced by four separate factors: the antigen, the adjuvant, the strain of mouse and the previous exposure of the mouse to the antigen. A sequence of 7S antibody production was detected in certain circumstances and characterized by an initial antibody consisting of fast (7S₁)-, and a later antibody of slow (7S₂)-globulin.

Footnotes

¹ This is publication number 128 from the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California.

This work was supported by United States Public Health Service Grant AI-03900.

² Supported by United States Public Health Service Training Grant 5T 1GM683.

Present address: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana.

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