HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Forbes, I. J. Search for Related Content PubMed PubMed Citation Articles by Forbes, I. J.

Mitosis in Mouse Peritoneal Macrophages

From the Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia

Abstract

Mitosis was induced in macrophages from the peritoneal cavity of sensitized mice by subcutaneous injection of specific antigen. Animals were best sensitized by intramuscular injection of antigen emulsified in Freund's complete adjuvant, but were capable of giving a less intense mitotic response after sensitization by intraperitoneal injection of antigen in saline.

Subcutaneous injection of fresh normal rabbit serum caused a small mitotic response, which was abolished by prior heating of the serum or absorption with mouse spleen cells.

The changes in the peritoneal cell population during a mitotic response are described. Appearances suggested that mitosis occurred in both "old" and "young" macrophages, and that "young" macrophages were derived from lymphocytes by transformation. Mitosis was infrequent in these cells having morphology intermediate between lymphocytes and macrophages. Macrophage destruction apparently occurred only in the most intense reactions.

Mitosis occurred when the peritoneal cavity was disturbed by repeated puncture of the abdominal wall. Mouse serum or plasma was found to be a potent stimulus to mitosis when injected intraperitoneally.

Induction of a mitotic response by injection of soluble antigen in sensitized mice did not affect the growth of Listeria monocytogenes in the spleens of these mice or the phagocytosis of Salmonella typhimurium C5.

This article has been cited by other articles:

				Y. Luo, S. C. Tucker, and A. Casadevall Fc- and Complement-Receptor Activation Stimulates Cell Cycle Progression of Macrophage Cells from G1 to S J. Immunol., June 1, 2005; 174(11): 7226 - 7233. [Abstract] [Full Text] [PDF]

				E. Shelton, S. Daves, and R. Hemmer Quantitation of Strain BALB/c Mouse Peritoneal Cells Science, June 5, 1970; 168(3936): 1232 - 1234. [Abstract] [PDF]