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Immunologic Response to the Nitro-Olefins¹

From the Department of Medicine of the State University of New York, Downstate Medical Center, Brooklyn, New York, and the Laboratory of Medical and Biological Sciences, Division of Air Pollution, United States Public Health Service, Cincinnati, Ohio

Abstract

The conjugated nitro-olefins have been shown to be effective agents in provoking delayed hypersensitivity in guinea pigs. Studies of a variety of substituted and unsubstituted, saturated and unsaturated hydrocarbons indicate that only the conjugated, nitro-substituted compounds are sensitizers. Examination of cross-reactivity between nitro-olefins of differing chain length indicates that specificity of the contact reactions is dependent, at least in part, upon the size of the haptenic moiety.

Footnotes

¹ Latter portion of this work was supported by the Health Research Council of the City of New York under Grant U-1420.

² Recipient of Career Investigatorship I-315 of the Health Research Council of the City of New York.