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Immunogenicity of Insolubilized Bovine Serum Albumin¹

From the Biochemical Research Department, Abbott Laboratories, North Chicago, Illinois, and the Department of Microbiology, Cornell University Medical College, New York, New York

Abstract

As compared with soluble bovine serum albumin, the use of the heat-denatured protein as an immunizing antigen in rabbits resulted both in a larger number of responding animals and in markedly higher serum antibody titers.

In measuring these titers, it was found that the lower the serum titer, the higher was the percentage of the nonprecipitating antibody in relation to the precipitating variety. Evidently, the appearance of nonprecipitating antibody preceded that of precipitating antibody.

Footnotes

¹ This work was carried out in part at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health. It was also supported by NIH Grant AI-06004 and NSF Grant GM-2042 to DHS.

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