| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From The Rockefeller University, New York, New York
Abstract
Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA. One dominant reaction was observed which was provisionally termed the Sm system. The antigen involved was identified in nuclei of a wide variety of cells from different species. It was associated with protein fractions but was a non-histone substance quite sensitive to periodate treatment. Antibodies to the Sm antigen could also be detected by complement fixation. They showed a high incidence in systemic lupus erythematosus with considerable specificity for the disease.
Footnotes
1 This investigation was supported in part by Public Health Service Grant No. FR-00102 from the General Clinical Research Centers Branch of the Division of Research Facilities and Resources and Public Health Service Grant No. 7 F2 AM-20, 122-02.
2 This work was done during the tenure of a postdoctoral fellowship from the Arthritis Foundation.
Present address, Washington University School of Medicine, St. Louis, Missouri.
This article has been cited by other articles:
|
|
 |
|
  O. Jin, S. Kavikondala, L. Sun, R. Fu, M.-Y. Mok, A. Chan, J. Yeung, and C.-S. Lau Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression Lupus, July 1, 2008; 17(7): 654 - 662. [Abstract] [PDF]
|
|
|
|
 |
|
 G. C. Tsokos In the Beginning Was Sm J. Immunol., February 1, 2006; 176(3): 1295 - 1296. [Full Text] [PDF]
|
|
|
|
|
|
L. Frisoni, L. Mcphie, L. Colonna, U. Sriram, M. Monestier, S. Gallucci, and R. Caricchio Nuclear Autoantigen Translocation and Autoantibody Opsonization Lead to Increased Dendritic Cell Phagocytosis and Presentation of Nuclear Antigens: A Novel Pathogenic Pathway for Autoimmunity? J. Immunol., August 15, 2005; 175(4): 2692 - 2701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mahler, L. M. Stinton, and M. J. Fritzler Improved Serological Differentiation between Systemic Lupus Erythematosus and Mixed Connective Tissue Disease by Use of an SmD3 Peptide-Based Immunoassay Clin. Vaccine Immunol., January 1, 2005; 12(1): 107 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Orton, A. Peace-Brewer, J. L. Schmitz, K. Freeman, W. C. Miller, and J. D. Folds Practical Evaluation of Methods for Detection and Specificity of Autoantibodies to Extractable Nuclear Antigens Clin. Vaccine Immunol., March 1, 2004; 11(2): 297 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P H Schur and M Liang Henry Kunkel Festschrift Lupus, March 1, 2003; 12(3): 153 - 156. [Abstract] [PDF]
|
|
|
|
|
|
S M Fu, J D Castillo, U S Deshmukh, J E Lewis, S T Waters, and F Gaskin Autoantibodies and glomerulonephritis in systemic lupus erythematosus Lupus, March 1, 2003; 12(3): 175 - 180. [Abstract] [PDF]
|
|
|
|
|
|
W H Reeves, S Narain, and M Satoh Henry Kunkel, Stephanie Smith, clinical immunology, and split genes Lupus, March 1, 2003; 12(3): 213 - 217. [Abstract] [PDF]
|
|
|
|
 |
|
 A. L. Hepburn and P. J. Charles Antinuclear factor Rheumatology, March 1, 2002; 41(3): 343 - 345. [Full Text] [PDF]
|
|
|
|
|
|
R N. Furtado, M L. Pucinelli, V V Cristo, L E. Andrade, and E I Sato Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients Lupus, January 1, 2002; 11(1): 35 - 41. [Abstract] [PDF]
|
|
|
|
 |
|
 R J Lock and D J Unsworth Antibodies to extractable nuclear antigens. Has technological drift affected clinical interpretation? J. Clin. Pathol., March 1, 2001; 54(3): 187 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A A Bengtsson, G Sturfelt, L Truedsson, J Blomberg, G Alm, H Vallin, and L Ronnblom Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies Lupus, November 1, 2000; 9(9): 664 - 671. [Abstract] [PDF]
|
|
|
|
|
|
L. J. Mason, L. M. Timothy, D. A. Isenberg, and J. K. Kalsi Immunization with a Peptide of Sm B/B' Results in Limited Epitope Spreading But Not Autoimmune Disease J. Immunol., May 1, 1999; 162(9): 5099 - 5105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Rowell Some historical aspects of skin disease in lupus erythematosus Lupus, January 1, 1997; 6(2): 76 - 83. [PDF]
|
|
|
|
|
|
H. Winska-Wiloch, S. Muller, D. Katz, L. Wilkinson, P. Hutchings, and D. Isenberg Immunogenic properties of synthetic fragments of Sm-D protein in normal and lupus mice Lupus, January 1, 1997; 6(8): 656 - 667. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Johansson-Stephansson, S. Koskimies, J. Partanen, and A.-L. Kariniemi Subacute Cutaneous Lupus Erythematosus: Genetic Markers and Clinical and Immunological Findings in Patients Arch Dermatol, June 1, 1989; 125(6): 791 - 796. [Abstract] [PDF]
|
|
|
|
 |
|
 J. F. Fries Advances in Management of Rheumatic Disease: 1965 to 1985 Arch Intern Med, May 1, 1989; 149(5): 1002 - 1011. [Abstract] [PDF]
|
|
|
|
|
|
E. A. Lerner and M. R. Lerner Whither the ANA? Arch Dermatol, March 1, 1987; 123(3): 358 - 362. [Abstract] [PDF]
|
|
|
|
|
|
H. L. Wechsler Lupus Erythematosus: A Clinician's Coign of Vantage Arch Dermatol, November 1, 1983; 119(11): 877 - 882. [Abstract] [PDF]
|
|
|
|
 |
|
 E. L. ALEXANDER, F. C. ARNETT, T. T. PROVOST, and M. B. STEVENS Sjogren's Syndrome: Association of Anti-Ro(SS-A) Antibodies with Vasculitis, Hematologic Abnormalities, and Serologic Hyperreactivity Ann Intern Med, February 1, 1983; 98(2): 155 - 159. [Abstract] [PDF]
|
|
|
|
|
|
R. D. SONTHEIMER, P. J. MADDISON, M. REICHLIN, R. E. JORDON, P. STASTNY, and J. N. GILLIAM Serologic and HLA Associations in Subacute Cutaneous Lupus Erythematosus, a Clinical Subset of Lupus Erythematosus Ann Intern Med, November 1, 1982; 97(5): 664 - 671. [Abstract] [PDF]
|
|
|
|
 |
|
 M Bustin, J Reisch, L Einck, and J. Klippel Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases Science, March 5, 1982; 215(4537): 1245 - 1247. [Abstract] [PDF]
|
|
|
|
|
|
S. Miyagawa, W. Kitamura, J. Yoshioka, and K. Sakamoto Placental Transfer of Anticytoplasmic Antibodies in Annular Erythema of Newborns Arch Dermatol, September 1, 1981; 117(9): 569 - 572. [Abstract] [PDF]
|
|
|
|
 |
|
 S. L. Forstot, J. Z. Forstot, C. L. Peebles, and E. M. Tan Serologic Studies in Patients With Keratoconjunctivitis Sicca Arch Ophthalmol, May 1, 1981; 99(5): 888 - 890. [Abstract] [PDF]
|
|
|
|
|
|
M. Lerner, J. Boyle, J. Hardin, and J. Steitz Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus Science, January 23, 1981; 211(4480): 400 - 402. [Abstract] [PDF]
|
|
|
|
|
|
R. K. Winkelmann and A. Padilha-Goncalves Connective Tissue Panniculitis Arch Dermatol, March 1, 1980; 116(3): 291 - 294. [Abstract] [PDF]
|
|
|
|
|
|
J. L. Millns, F. C. McDuffie, S. A. Muller, and R. E. Jordon Development of Photosensitivity and an SLE-like Syndrome in a Patient With Psoriasis Arch Dermatol, August 1, 1978; 114(8): 1177 - 1181. [Abstract] [PDF]
|
|
|
|
|
|
V. Kumar, W. L. Binder, E. Schotland, E. H. Beutner, and T. P. Chorzelski Coexistence of Bullous Pemphigoid and Systemic Lupus Erythematosus Arch Dermatol, August 1, 1978; 114(8): 1187 - 1190. [Abstract] [PDF]
|
|
|
|
|
|
S. D. Prystowsky and D. L. Tuffanelli Speckled (Particulate) Epidermal Nuclear IgG Deposition in Normal Skin: Correlation of Clinical Features and Laboratory Findings in 46 Patients With a Subset of Connective Tissue Disease Characterized by Antibody to Extractable Nuclear Antigen Arch Dermatol, May 1, 1978; 114(5): 705 - 710. [Abstract] [PDF]
|
|
|
|
|
|
W. R. Bell, G. R. Boss, and J. S. Wolfson Circulating Anticoagulant in the Procainamide-Induced Lupus Syndrome Arch Intern Med, October 1, 1977; 137(10): 1471 - 1473. [Abstract] [PDF]
|
|
|
|
|
|
J. N. Gilliam and S. D. Prystowsky Mixed Connective Tissue Disease Syndrome: Cutaneous Manifestations of Patients With Epidermal Nuclear Staining and High Titer Serum Antibody to Ribonuclease-Sensitive Extractable Nuclear Antigen Arch Dermatol, May 1, 1977; 113(5): 583 - 587. [Abstract] [PDF]
|
|
|
|
|
|
S. J. Farber and G. G. Bole Antibodies to Components of Extractable Nuclear Antigen: Clinical Characteristics of Patients Arch Intern Med, April 1, 1976; 136(4): 425 - 431. [Abstract] [PDF]
|
|
|
|
|
|
D. L. Tuffanelli Lupus Erythematosus Arch Dermatol, October 1, 1972; 106(4): 553 - 566. [Abstract] [PDF]
|
|
|
|
|
|
B. H. HAHN, G. C. SHARP, W. S. IRVIN, O. S. KANTOR, C. A. GARDNER, M. K. BAGBY, H. M. PERRY JR., and C. K. OSTERLAND Immune Responses to Hydralazine and Nuclear Antigens in Hydralazine-Induced Lupus Erythematosus Ann Intern Med, March 1, 1972; 76(3): 365 - 374. [Abstract] [PDF]
|
|
|
|
|
|
K. H. Svec and S. T. Allen Antibody to Nuclear Material Eluted from Isolated Spleen Vessels in Systemic Lupus Erythematosus Science, October 30, 1970; 170(3957): 550 - 551. [Abstract] [PDF]
|
|
|
|
|
|
R. T. Wold, F. E. Young, E. M. Tan, and R. S. Farr Deoxyribonucleic Acid Antibody: A Method to Detect Its Primary Interaction with Deoxyribonucleic Acid Science, August 23, 1968; 161(3843): 806 - 807. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
