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Immunoglobulin Patterns of Antibodies against Brucella in Man and Animals

From the University Department of Bacteriology, Western Infirmary, Glasgow W.1., Scotland

Abstract

Agglutinating antibodies against Brucella were found in each of the three immunoglobulin fractions, G, A and M, in human sera and in analogous fractions in cattle and rabbit sera. In cattle, 1 month after immunization with Brucella abortus, most of the agglutinating antibody was in the macroglobulin fraction. At later intervals, a higher proportion of 7 S antibody was found. Blocking antibodies in two sera taken from late cases of human brucellosis were present in the G- and A-globulin fractions, but were absent from the M-globulin fraction of these sera.

Footnotes

¹ Supported in part by the Medical Research Council.

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