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The Antigenic Structure of Treponema Pallidum, Nichols Strain

I. The Demonstration, Nature and Location of Specific and Shared Antigens¹

From the Laboratory of Bacteriology and Serology, National Institute of Public Health, Utrecht, Netherlands

Abstract

Relatively tissue-free suspensions of Treponema pallidum, Nichols strain, were prepared by extracting the organism in rabbit serum-saline medium in equal parts. They were exposed to ultrasonic disintegration and the presence of antigens within the lysate and residue determined. Heat-labile and heat-stable (non-cardiolipin) antigens specific for T. pallidum, as well as antigens related to the lipopolysaccharide and protein (RP) components of the nonpathogenic Treponema reiteri, could be demonstrated. Further, the above antigens were shown to be unrelated to TPI antigen(s). The specific T. pallidum antigens within the lysate were found to be distinct from those within the residue.

Footnotes

¹ These studies were carried out while the senior author was on sabbatical leave from the Department of Medical Microbiology and Immunology, University of California School of Medicine, Los Angeles, California. They were supported in part by a United Health Foundation Fellowship Grant from the New York Academy of Medicine, and in part by United States Public Health Service Research Grant CC-00115 from the Communicable Disease Center, Atlanta, Georgia.