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Early Antibody Responses of Mice Given a Single Injection of Emulsified Influenza Virus Vaccine

From the Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

Sucrose gradient centrifugation and susceptibility to 2-mercaptoethanol were employed to identify M and G antibodies and to study the kinetics of antibody formation in mice injected with a single dose of emulsified influenza virus vaccine. Theoretical considerations based on the shapes of M and G response curves indicate that M antibody was produced and subsequently catabolized at a faster rate than G antibody. In addition, the mineral oil adjuvant increased production of M and G antibodies, although the effect on G production was more striking.

Footnotes

¹ This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, and was supported by the Office of the Surgeon General, U.S. Army, Washington, D.C.