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A Hemagglutination Test and a Specific Depolymerase for Studying Immunologic Paralysis in Mice¹

From the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts

Abstract

The specificity of a hemagglutination test for detecting antibodies against the polysaccharide of type III Diplococcus pneumoniae (SIII) and the ability of a specific depolymerase to clear the SIII from the blood of mice are described. Mice injected with relatively large quantities of SIII are specifically prevented from responding to further immunogenic doses of that antigen.

The response of different strains of mice injected with varying quantities of SIII is compared on the basis of the hemagglutination and challenge tests.

Footnotes

¹ This work was supported by Grant CA-05175 from the National Institutes of Health, United States Public Health Service.