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The in Vitro and in Vivo Effects of Cortisol on Interferon Production and Action¹

From the Departments of Microbiology and Pediatrics, University of Rochester School of Medicine, Rochester, New York

Abstract

Using the plaque reduction assay for interferon, it was found that cortisol inhibited inter feron production in infections with either an RNA (Chikungunya) or a DNA (vaccinia) virus in vitro. The depression of interferon production was not associated with an increased rate of virus replication. There was no effect of cortisol on the anti-viral activity of interferon in vitro. In vivo, the injection of cortisol 1 hr before an experimental viremia significantly reduced the amount of interferon in the sera of mice 4.5 to 6 hr after infection.

Footnotes

¹ Presented in part at the 65th annual meeting of the American Society of Microbiology, Atlantic City, April 1965. This investigation was partially supported by Public Health Service Grant No. A1-06388 and Training Grant No. 2T1 A1 28 of the National Institute of Allergy and Infectious Diseases.

² Address reprint requests to L. A. Glasgow.