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The Induction of a Hyporesponsive State to Hemocyanin¹

From the Scripps Clinic and Research Foundation, Division of Experimental Pathology, La Jolla, California

Abstract

An immunologic hyporesponsive state can readily be induced in rabbits to hemocyanin by neonatal injection of either associated hemocyaanin or hemocyanin dissociated into its subunits. The injection of associated hemocyanin was slightly more effective than that of dissociated hemocyanin. However, neonatal injection of large amounts of dissociated hemocyanin resulted in over a 90% reduction in the production of precipitating antibody to injections of hemocyanin at maturity. Some rabbits made no detectable precipitating antibody. Hyporesponsive rabbits made an abortive secondary response to the challenge injection at maturity, indicating the presence of unresponsive and hyperresponsive states in the same animal. Rabbits rendered hyporesponsive to one type (associated or dissociated) of hemocyanin were hyporesponsive to the other type.

Footnotes

¹ This is publication number 141 from the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. The work was supported by a United States Public Health Grant AI-03882 and Atomic Energy Commission Contract AT(04-3)-410.

² Supported by United States Public Health Service Research Career Award K6-GM-6936.