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The Journal of Immunology, 1966, 96: 311-318.
Copyright © 1966 by The American Association of Immunologists, Inc.
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Hemagglutination-Inhibiting Antibody Responses in Human Infections with Group B Coxsackieviruses1

Nathalie J. Schmidt, Edwin H. Lennette and Juanita Dennis

From the Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, California

Abstract

Hemagglutination-inhibiting (HI) antibody responses for coxsackievirus types B1, B3 and B5 were compared with neutralizing antibody responses with respect to sensitivity, specificity and diagnostic value in patients with and without coxsackievirus infections. Most sera possessed nonspecific inhibitors for hemagglutinins of these viral types, but treatment of sera with filtrates from a psychrophylic Pseudomonas sp. was found to be highly effective for removing such inhibitors; this treatment appeared to have little or no detrimental effect on specific antibody. HI tests on treated sera were comparable to neutralization tests in diagnostic value, with 46% of patients with isolations of coxsackievirus types B1, B3 and B5 showing significant rises in homotypic antibody titers by both tests. Heterotypic antibody rises seen in HI tests on treated sera corresponded with those observed in neutralization tests. HI antibody was rarely observed in treated sera in the absence of neutralizing antibody for the corresponding viral type.

Footnotes

1 The work on which this article is based was supported by Grant AI-01475-08 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare.






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