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The Journal of Immunology, 1966, 96: 304-310.
Copyright © 1966 by The American Association of Immunologists, Inc.
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Heterogeneity of Immune Anti-A Antibody in Relation to Forssman Antigen1

Mitsuo Yokoyama2 and H. H. Fudenberg

From the Department of Genetics, University of Hawaii, Honolulu, Hawaii, and the Hematology Unit, Department of Medicine, University of California School of Medicine, San Francisco, California

Abstract

Guinea pig antigen, sheep red cells (type R), human group A1 red cells and soluble specific blood group substance A contain a similar A-like antigenic determinant. The A-like antigen of certain pig red cells (API) reacts with "immune" but not with "naturally occurring" anti-A antibody in human serum. Pig Ap red cells also absorb anti-sheep red cell hemolysin from human sera containing "immune" anti-A antibody, but not from those containing "naturally occurring" anti-A; furthermore, such cells do not absorb the anti-sheep red cell hemolysin present in immune rabbit serum. These results suggest that immune group O sera may contain an antibody specific against both A antigen and Forssman antigen.

Footnotes

1 Supported by Grants AM-8527 and H-5997 from the United States Public Health Service and by Contract Nonr-3656(12) (NR 105-308) between the Office of Naval Research, Department of the Navy, and the Department of Medicine, University of California School of Medicine, San Francisco, California.

Genetic paper no. 7-112, Pacific Biomedical Research Center Contribution.

2 Formerly Assistant Research Hematologist, University of California Medical Center, San Francisco, California.






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