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The Immune Response to Circulating Autologous Hepatocellular Antigens¹

From the Division of Immunochemistry and Allergy, McGill University Clinic, Royal Victoria Hospital, Montreal, Canada

Abstract

The injection of thioacetamide into rats resulted in the release of hepatocellular-specific antigens into the systemic circulation. These hepatic proteins remained in the circulation for 1 to 2 days. Circulating autoantibodies, directed to autologous liver antigens, were detected about a week later in the sera of only 2 of the 20 rats.

Footnotes

¹ Supported by grants from the Medical Research Council, Canada, and the Canadian Cancer Society, Canada.

This work was presented, in part, at the Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, 1962 (Fed. Proc., 21:20, 1962).

² Fellow of the Canadian Arthritis and Rheumatism Society, Canada. Submitted in partial fulfillment for the Degree of Doctor of Philosophy, Department of Experimental Medicine, McGill University.

³ Special Research Fellow, United States Public Health Service.

⁴ Medical Research Associate, Medical Research Council, Canada.