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Immunofluorescent Studies on Rubella-Infected Tissue Cultures and Human Tissues¹

From the Departments of Pediatrics and Medicine (Division of Neurology), Cleveland Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland, Ohio

Abstract

Specific viral antigen has been demonstrated in the cytoplasm of two types of tissue culture cells (RK13, GMKH) by the technique of indirect immunofluorescence.

Employing the same reagents, discrete foci of fluorescent cells were demonstrated in the heart and skeletal muscle of an infant with the rubella syndrome who died on the 6th day of life. Although final proof is lacking, this finding is presumed to indicate rubella virus infection in these areas. An interfering agent was isolated from the heart of this infant which was not finally identified as rubella virus. However, rubella virus was isolated from the pharynx of a surviving twin who also had classical features of the rubella syndrome.

Footnotes

¹ This work was supported in part by United States Public Health Service Research Grants NB-05244 (National Institute of Neurological Diseases and Blindness) and 5 RO1 AI05770-02 (National Institute of Allergy and Infectious Diseases), and by Contract DA-49-193-MD-2237 from the United States Army Medical Research and Development Command.

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