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Studies on Antigenic Composition of Amyloid¹

From the Department of Bacteriology and Immunology and the Department of Medicine, State University of New York at Buffalo, Buffalo, New York

Abstract

By means of rabbit immunosera, two antigenic components were found in extracts of amyloidcontaining human organs, which were not detectable in extracts of organs without amyloid.

In immunoelectrophoresis, the major components had faster mobility and stained positively with Sudan black; the minor component appeared in the -globulin region of the electrophoretic field.

Evidence was presented that these components are most likely to be normal serum proteins which were concentrated in the amyloid deposits.

Footnotes

¹ This investigation was supported by Research Grant AM-05581-04 and Training Grant T1 AM-5075-10 from the National Institute of Arthritis and Metabolic Disease, United States Public Health Service.

² Fellow of the Western New York Chapter of the Arthritis and Rheumatism Foundation.