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The Relation Between Isolated Human Amyloid Fibrils and Human -Globulin and Its Subunits¹

From the Robert Dawson Evans Department of Clinical Research, University Hospital, The 5th & 6th (Boston University) Medical Services, Boston City Hospital, and the Department of Medicine, Boston University School of Medicine, Boston University Medical Center

Abstract

Purified amyloid fibrils from three separate spleens obtained from patients with primary and secondary disease were used to determine the relation between human amyloid fibrils and human -globulin and its subunits. Results demonstrated no reaction a) when solubilized amyloid fibrils were tested against specific antisera to whole human -globulin and some of its components; b) when specific components of human -globulin were tested against antiserum to solubilized amyloid fibrils and c) when intact lyophilized amyloid fibrils were tested against specific antisera to whole human -globulin and some of its components. The probable nonspecific relation of amyloid fibrils to -globulin was discussed.

Footnotes

¹ Grants in support of these investigations have been received in part from United States Public Health Service Grants Nos. AM-05589, AM-04599 and T1-AM-5285.