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Studies on Heterologous Anti-Lymphocyte Serum in Mice

II. Effect on the Immune Response¹

From the Department of Surgery, Harvard Medical School, the General Surgical Services, Massachusetts General Hospital, and the J. Collins Warren Laboratories of the Huntington Memorial Hospital of Harvard University

Abstract

1. Rabbit anti-A/Jax lymphocyte serum (RAMLS) given to A/Jax mice inhibits the primary and, to some extent, the secondary hemagglutinin response to sheep erythrocytes.

2. RAMLS-treated mice show decreased ability to reject first and second set skin allografts and rat skin xenografts.

3. Prolongation of skin allografts by RAMLS is probably due to a central inhibition of the allograft rejection response.

4. The crude -globulin fraction extracted from RAMLS is as effective in inhibiting the allograft response as the whole serum.

5. The ability of RAMLS to inhibit the allograft rejection response is not due to the antibodies to mouse -globulin present in the RAMLS.

6. RAMLS is a potent biologic reagent for the induction of states of lymphocyte depletion.

Footnotes

¹ This work was supported in part by Grants AM 07055, AI 06320, T4 CA 5018 and CRTY 5018 from the United States Public Health Service and by the William F. Milton Fund of the Harvard University.

This is publication No. 1236 of the Cancer Commission of Harvard University.

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