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Viruria in Herpes Simplex Infection of Mice¹

From the Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts

Abstract

Male mice injected intravenously with herpes simplex virus manifested a fatal ascending paralysis which was associated with viruria in 34% of 101 mice tested. Virus recovery was from spontaneously voided as well as directly aspirated urine specimens. Viruria was detected only in paralyzed mice dying of the infection and not in injected mice without paralysis or in uninfected control cagemates. Viruria occurred as early as 4 days and as late as 12 days after injection, depending on the amount of virus injected. Most animals excreted from 10 to 1000 TCID₅₀/ml of urine and, once demonstrated, viruria persisted until death. Simultaneously measured blood levels of virus were not sufficiently high to suggest direct passage of virus from blood to urine. It was concluded, therefore, that viruria occurred as a result of virus multiplication in the genitourinary tract in the course of this disseminated infection.

Footnotes

¹ Presented, in part, before the Central Society for Clinical Research, 36th Annual Meeting, November 1963, Chicago, Illinois.

Study carried out in partial fulfillment of the requirements for the degree of Doctor of Science in Hygiene in the Field of Tropical Public Health. Supported in part by Public Health Service Research Grant AI-01023 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and (in part) by a grant from Parke, Davis and Company.

² Postdoctoral fellow of the Institute of Allergy and Infectious Diseases, National Institutes of Health.