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Preparations of Saliva Inhibiting Reovirus Hemagglutination¹

From the Departments of Medicine and Microbiology and the Detroit General Hospital, Wayne State University School of Medicine, Detroit, Michigan

Abstract

Substance(s) in saliva have been found which inhibit hemagglutination by reoviruses, type 1, 2 or 3. They attach to capsid protein of the virus, but not irreversibly to the erythrocyte. In complexing to virus, the sedimentation rate of the virus as determined by sucrose gradient ultracentrifugation may be altered.

These salivary substances are absorbed by kaolin, and are not identical to blood group substances A, B or H. They are probably mucins and indicate further affinity of reoviruses for glycoproteins.

Footnotes

¹ Aided by Grants 5 TI AI 261-02 and AI-05721-02 from the National Institutes of Health.

² Associate Professor of Medicine and Associate in Microbiology and Pathology, Wayne State University School of Medicine; Director of Bacteriology Laboratory and Chief of Infectious Diseases, Detroit Receiving Hospital, Detroit, Michigan.

³ Head Laboratory Technician, Infectious Disease Laboratory, Wayne State University School of Medicine, Detroit, Michigan.

⁴ Senior Medical Student, Wayne State University School of Medicine, Detroit, Michigan.