HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kundin, W. D. Search for Related Content PubMed PubMed Citation Articles by Kundin, W. D.

Pathogenesis of Venezuelan Equine Encephalomyelitis Virus

II. Infection in Young Adult Mice¹

From the Section of Virus Research, Department of Pediatrics, and the Department of Microbiology, University of Kansas School of Medicine, Kansas City, Kansas

Abstract

The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis (VEE) virus was studied in young adult mice by means of infectivity titrations and fluorescent antibody staining. Tissue infectivity and viral lethality were generally similar in mice inoculated intracerebrally (i.c.) or subcutaneously (s.c.) with unattenuated virus and i.c. with attenuated virus. The tissues most involved were brain, salivary glands, inguinal nodes and spleen. Mice inoculated s.c. with attenuated VEE virus survived the infection. Little virus was found in the brain.

Footnotes

¹ Supported by a grant from the United States Army Biological Laboratories, Ft. Detrick, Maryland.

In conducting the research project herein, the investigators adhered to "Principles of Laboratory Animal Care" as established by the National Society for Medical Research.

² Present address: G. W. Hooper Foundation, University of California, % Institute for Medical Research, Kuala Lumpur, Malaysia.

This article has been cited by other articles:

				C. T. Rosas, S. Paessler, H. Ni, and N. Osterrieder Protection of Mice by Equine Herpesvirus Type 1 Based Experimental Vaccine against Lethal Venezuelan Equine Encephalitis Virus Infection in the Absence of Neutralizing Antibodies Am J Trop Med Hyg, January 1, 2008; 78(1): 83 - 92. [Abstract] [Full Text] [PDF]

				S. Paessler, H. Ni, O. Petrakova, R. Z. Fayzulin, N. Yun, M. Anishchenko, S. C. Weaver, and I. Frolov Replication and Clearance of Venezuelan Equine Encephalitis Virus from the Brains of Animals Vaccinated with Chimeric SIN/VEE Viruses J. Virol., March 15, 2006; 80(6): 2784 - 2796. [Abstract] [Full Text] [PDF]

				S. Paessler, R. Z. Fayzulin, M. Anishchenko, I. P. Greene, S. C. Weaver, and I. Frolov Recombinant Sindbis/Venezuelan Equine Encephalitis Virus Is Highly Attenuated and Immunogenic J. Virol., September 1, 2003; 77(17): 9278 - 9286. [Abstract] [Full Text] [PDF]