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The Journal of Immunology, 1966, 96: 39-46.
Copyright © 1966 by The American Association of Immunologists, Inc.
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Pathogenesis of Venezuelan Equine Encephalomyelitis Virus

I. Infection in Suckling Mice1

William D. Kundin2, Chien Liu3 and Patricia Rodina

From the Section of Virus Research, Department of Pediatrics, The Department of Microbiology and the Department of Medicine, University of Kansas School of Medicine, Kansas City, Kansas

Abstract

The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis virus infection in suckling mice as studied by infectivity titrations and direct fluorescent antibody-staining technique was described. Both strains of VEE virus caused a pantropic infection in suckling mice regardless of the concentration of inoculum used or the route of inoculation given. Viral antigen was detected in many tissues, notably in the central nervous system and in the pancreas. However the intensity of antigenic fluorescence was rather weak, making it difficult to discern sequential development of the viral antigen in infected tissues.

Footnotes

1 Supported by a grant from the United States Army Biological Laboratories, Ft. Detrick, Maryland.

In conducting the research project herein, the investigators adhered to "Principles of Laboratory Animal Care" as established by the National Society for Medical Research.

2 Present address: G. W. Hooper Foundation, University of California, % Institute for Medical Research, Kuala Lumpur, Malaysia.

3 Research Career Awardee (5-K6-AI-1826), National Institutes of Health, United States Public Health Service.






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