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Alteration of the Specificity of Lectin by Chemical Modification. II¹

From the Boston University School of Medicine, Boston, Massachusetts

Abstract

The effects on the blood group specificity of lima bean anti-A of coupling to it diazotized amino derivatives of D-glucose and D-galactose were investigated. The galactose derivatives all enhanced the anti-B activity, p-aminophenyl--N-acetyl-D-galactosaminide (Ga III) being the most effective. Some of the glucose derivatives also enhanced the anti-B activity, but tended more to confer also an anti-O activity. The anti-B activity of these modified lectins was inhibited by 1 M D-galactose, and all activity inhibited by N - acetyl - D - galactosamine. Possible chemical mechanisms of the observed changes are discussed.

Footnotes

¹ The research reported in this article was supported by grants GM-04704, GM-06939 and HE-01076 from the United States National Institutes of Health and Research Grant NSF-GB-2219 from the National Science Foundation. W. C. B. is the recipient of National Institutes of Health research career award K6-6M-14, 194-03.

² Present address: Universität Bern, Bühlstrasse 28, Bern, Switzerland.