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The Journal of Immunology, 1966, 96: 17-24.
Copyright © 1966 by The American Association of Immunologists, Inc.
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Role of Interferon during Viremia

II. Protective Action of Circulating Interferon

Samuel Baron, Charles E. Buckler, Robert M. Friedman and Richard V. McCloskey1

From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Laboratory of Biology of Viruses, Laboratory of Pathology and Laboratory of Tropical Virology, Bethesda, Maryland

Abstract

Circulating interferon was shown to protect mice against intracerebral challenge with encephalomyocarditis or vesicular stomatitis viruses, against intraperitoneal challenge with Germiston virus and intradermal infection with vaccinia virus. The possibility that circulating interferon provides similar protection during natural infection, is considered.

Footnotes

1 Present address: Duke University Medical Center, Durham, North Carolina.






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