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Arthus Type Inflammation with Rabbit M Antibody¹

From the Children's Asthma Research Institute and Hospital, Denver, Colorado

Abstract

Rabbit M antibody against human type A substance gave precipitin reactions in vitro and induced reversed Arthus type of inflammation in guinea pigs which had received A substance. Preformed complexes composed of A substance and M antibody also induced the allergic inflammation in normal guinea pig skin. On a weight basis, the minimum dose of the M antibody for the induction of hemorrhage in reversed Arthus reactions was two to four times as much as the dose of the G antibody. In the reactions by the preformed complexes, a similar dose of M and G antibody in the form of complexes with A substance induced comparable skin reactions.

Footnotes

¹ This work was supported by Research Grant AI-4985 from the United States Public Health Service.