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The Separation and Physicochemical Properties of the C and D Antigens of Coxsackievirus¹

From the Exobiology Division, NASA, Ames Research Center, Moffett Field, California

Abstract

The two antigens of coxsackievirus, Type B-5, separated by centrifugation in sucrose and cesium chloride density gradients, were shown to be very similar to the C and D antigens of poliomyelitis virus in their infectivity, complement-fixing properties, particle size and shape, and nucleic acid content. Certain practical aspects of the efficiency of separation of the C and D antigens in sucrose and cesium chloride density gradients were also discussed.

Footnotes

¹ This investigation was supported in part by Grant E-1475 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, United States Department of Health, Education, and Welfare, to the California State Health Department.