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Experimental Rubella Virus Infection in the Rhesus Monkey

From the United States Department of Health, Education, and Welfare, Public Health Service, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland

Abstract

The rhesus monkey has been shown to be a sensitive, susceptible host for studying experimental rubella virus infection. The pattern of virus excretion and antibody response was similar to that observed in human rubella, although simian infection was clinically inapparent. Antibody persisted for at least 10 months and was protective against virus challenge. After direct central nervous system (CNS) inoculation, prolonged viral multiplication occurred locally. However there was no evidence of neurovirulence. The potential usefulness of the monkey in studying maternal-fetal rubella was discussed.