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Inhibition of Antibody Production and Acquired Immunologic Tolerance by Actinomycin¹

From the Departments of Medicine and Pediatrics, University of Colorado Medical Center, Denver, Colorado

Abstract

1. Actinomycin D delays the appearance of circulating antibody to Bentonite-bovine -globulin (BGG).

2. Actinomycin D converts the tolerogenic property of soluble BGG to an immunogenic stimulus. This adjuvant effect of actinomycin is not seen with 6-mercaptopurine, 5-fluorouracil, nitrogen mustard or cyclophosphamide.

3. The ability of actinomycin to inhibit the tolerance produced by soluble BGG is considered a) as a possible result of inhibition of a repressor of antibody production, b) as a possible result of an alteration in antigen processing.

Footnotes

¹ Supported in part by United States Public Health Service Grants No. AM 07529 and 5T1 AI 13.