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Immunologic Unresponsiveness Appearing after Topical Application of Contact Sensitizers to the Guinea Pig¹

From the Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan

Abstract

Following the topical application of a sensitizer, a state of haptene-specific unresponsiveness to the compound regularly appears. This was demonstrated with three sensitizers: p-nitrosodimethylaniline (NDMA), dinitrochlorobenzene (DNCB) and chlorprothixene (CPT). Unresponsiveness may appear following application of minute quantities of a sensitizer (e.g., 25 NDMA) to the skin without further exposure to the compound prior to challenge. In the case of NDMA, unresponsiveness develops to maximum expression within 40 days of the initial topical exposure; unresponsiveness to a weaker sensitizer such as CPT appears more rapidly. A quantity of NDMA which is sufficient to induce unresponsiveness when put on the skin usually elicits a mild degree of sensitivity also. In the case of CPT, however, unresponsiveness is readily produced by topical applications which produce no detectable degree of sensitivity.

Footnotes

¹ Supported by United States Public Health Service Grant AI-06449-01.