HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Michaeli, D. Articles by Feingold, B. F. Search for Related Content PubMed PubMed Citation Articles by Michaeli, D. Articles by Feingold, B. F.

The Role of Collagen in the Induction of Flea Bite Hypersensitivity¹

From the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospitals, San Francisco, California

Abstract

Salt-soluble and acid-soluble collagens were isolated from guinea pig skin following bites of fleas, and were shown to possess the capacity to induce flea bite hypersensitivity upon injection into recipient guinea pigs. Less salt-soluble collagen was required for induction of sensitivity than was acid-soluble collagen. Flea hapten associated with salt-soluble collagen did not hinder the latter's in vitro reconstitution. The in vitro reconstituted product served as a better carrier for the hapten than the nonreconstituted form.

Footnotes

¹ This work was supported by Grant No. AI-3966-04 from the National Institutes of Health, United States Public Health Service.