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Blood Groups in the Rabbit

Two Additional Isoantibodies and the Red Cell Antigens They Identify¹

From the Department of Biology, Western Reserve University, Cleveland, Ohio

Abstract

Two new isoantibodies have been prepared which detect the antigenic products for the heretofore immunologically undetectable alleles at two blood group loci of the rabbit. Three of the five known blood group systems of the rabbit can now be completely identified. Both antibodies are of the 19 S variety and will agglutinate the corresponding red blood cells in saline. The anti-L is a good dosage serum, and the L antigen is much stronger than the antigenic product of its allele. The L antigen does not play a role in fetal-maternal isoimmunization, nor is it an effective histocompatibility antigen. The reaction of anti-M with its corresponding erythrocytic antigen is not strong, as is also characteristic of the reaction of the antibody to the antigen controlled by its allele.

Footnotes

¹ This investigation was supported in part by Research Grant GM 10444 from the Division of General Medical Sciences, National Institutes of Health, United States Public Health Service.