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II. Reverse Passive Cutaneous Anaphylaxis in the Guinea Pig with Ovalbumin

From the Centre de Recherches Allergiques et Immunologiques de l'Institut National d'Hygiène and the Association Claude Bernard, Hôpital Broussais, 96 rue Didot, Paris 14, France

Abstract

Reverse passive cutaneous anaphylaxis with ovalbumin and rabbit anti-ovalbumin antibody has been regularly produced in guinea pigs.

The quantity of antibody necessary to elicit such reactions was found to be the same as that required to sensitize guinea pig skin for direct anaphylaxis in a few minutes after the intravenous injection of antibody.

It may be concluded that in explanation of anaphylactic reactions in guinea pigs in the direct as well as the reverse procedure, since antibody "fixation" appears to be unnecessary in sensitizing guinea pig tissues, one can invoke an antigen-antibody system giving rise to complexes toxic for the guinea pig, providing some quantitative conditions have been respected.