HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Friedman, H. Search for Related Content PubMed PubMed Citation Articles by Friedman, H. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Immunization

Adoptive Tolerance to Shigella Antigen in Irradiated Mice Receiving Spleen Cell Transplants from Unresponsive Donors¹

From the Departments of Microbiology, Albert Einstein Medical Center and Temple University School of Medicine, Philadelphia, Pennsylvania

Abstract

1. Spleen cell suspensions from young mice immunologically tolerant to Shigella paradysenteriae antigens, induced by neonatal injection of a large inoculum of the antigen, were not competent to form agglutinins when transferred to lethally x-irradiated recipient mice.

2. Challenge injection of irradiated recipients with Shigella antigen at various time intervals following spleen cell transfer from Shigellatolerant donor mice did not result in normal levels of agglutinins, as occurred following transfer of spleen cells from normal or Shigella-immune donors.

3. Irradiated mice receiving unresponsive spleen cells were capable of forming normal levels of antibody to sheep erythrocytes or bovine serum albumin.

4. Adoptive tolerance could not be demonstrated with any degree of confidence in non-irradiated recipients capable of actively forming antibody to Shigella antigens, either with or without spleen cell transfer from normal, Shigella tolerant or Shigella immune donors.

Footnotes

¹ Supported in part by grants from the National Science Foundation.

This article has been cited by other articles:

				D. S. Strayer, H. Cosenza, W. M. F. Lee, D. A. Rowley, and H. Kohler Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor Science, November 15, 1974; 186(4164): 640 - 643. [Abstract] [PDF]

				H. Friedman L-Asparaginase Induced Immunosuppression: Inhibition of Bone Marrow Derived Antibody Precursor Cells Science, October 8, 1971; 174(4005): 139 - 141. [Abstract] [PDF]