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Studies on the Terminal Steps of Immune Hemolysis

II. Resolution of the E* Transformation Reaction into Multiple Steps

From the Laboratory of Clinical Science, National Institute of Mental Health, and the Diagnostic Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Abstract

Lysis of E* requires at least three separate reactions. Evidence is presented that the first step in the sequence of reactions is a temperature-dependent activation that takes place in the presence of 0.09 M ethylenediaminetetracetate (EDTA). The activation is followed by two steps that are relatively temperature-independent. The first of these can be blocked by 0.09 M EDTA, and the second can be blocked by 25% bovine plasma albumin.