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The Effect of Endotoxin on Skin Homografts in Rabbits¹

From the Departments of Urology and Medicine, New York University School of Medicine, New York, New York

Abstract

1. Administration of endotoxin to rabbits results in the accelerated rejection of first-set skin homografts.

2. The production of endotoxin tolerance suspends this effect of endotoxin on first-set skin homografts.

3. This action of endotoxin is limited to homografts and does not affect autografts.

Footnotes

¹ This study was supported by United States Public Health Service grant no. AI-01254 and the Streptococcal and Staphylococcal Commission of the Armed Forces Epidemiological Board.

² Supported by Contract No. U. 1062 from the Health Research Council of the City of New York.

³ Supported by U.S.P.H.S. Career Development Award GM-K3-15, 491-04.