The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1964, 93: 481-488.
Copyright © 1964 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prager, M. D.
Right arrow Articles by Bearden, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prager, M. D.
Right arrow Articles by Bearden, J.

Blood Group Antibody Activity among {gamma}1A-Globulins1

Morton D. Prager and Jane Bearden2

From the Wadley Research Institute and Blood Bank and the Graduate Research Institute of Baylor University, Dallas, Texas

Abstract

Evidence is presented that {gamma}1A-globulins carry specific blood group antibody activity. In Coombs-like reactions anti-{gamma}1A uniformly agglutinated anti-D and anti-G sensitized RBC but only rarely agglutinated cells sensitized by antibodies to other blood group factors. When found in these other blood group systems, the agglutination reactions were weak. Addition of purified {gamma}1A-globulin to anti-{gamma}1A-globulin and to anti-{gamma}-globulin reduced the ability of the former to agglutinate anti-D sensitized red cells but was without effect on anti-{gamma}-globulin reactions. Fractionation of various antisera by DEAE-cellulose chromatography and by sucrose density gradient centrifugation led to identification of the {gamma}1A antigen only in those antibodies in which it was detected in studies with whole serum. Presumptive evidence is presented that {gamma}1A-globulins in various states of polymerization may function as antibodies.

Footnotes

1 This work was supported by Grant AM-02612 from the National Institutes of Health.

2 This material was taken from a thesis prepared by Jane Bearden in partial fulfillment of the requirements of the Graduate School of Baylor University for the M.S. degree.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1964 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1964 by The American Association of Immunologists, Inc. All rights reserved.