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Delayed Hypersensitivity in Vitro

II. Effect of Sensitive Cells on Normal Cells in the Presence of Antigen¹

From the Department of Medicine, New York University School of Medicine, New York, New York

Abstract

Peritoneal exudate cells from guinea pigs exhibiting delayed hypersensitivity to tuberculin and from normal animals were mixed in varying proportions, and their migration in the presence of specific antigens was studied. The results indicate that only a few cells in a mixed population need be specifically sensitive to influence the behavior of the whole population. Killing the sensitive cells abolishes their effect on normal cells. Some questions raised by these results are discussed.

Footnotes

¹ Presented in part at the 47th Annual Meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 16 to 23, 1963.

Supported in part by a grant from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, A1-01254, and in part by the Streptococcal and Staphylococcal Disease Commission of the Armed Forces Epidemiological Board.

² Supported by United States Public Health Service Training Grant E.T.S. 2E-5.

³ United States Public Health Service Career Development Award GM-K3-15, 491-03.

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