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Delayed Hypersensitivity in Vitro

I. The Specificity of Inhibition of Cell Migration by Antigens¹

From the Department of Medicine, New York University School of Medicine, New York, New York

Abstract

1. The migration of peritoneal exudate cells from guinea pigs with delayed hypersensitivity to tuberculin purified protein derivative, ovalbumin and diphtheria toxoid is markedly inhibited by the respective antigen, and such inhibition is specific.

2. Cells from guinea pigs producing precipitating antibody are not inhibited by antigen.

3. Sera from experimental animals exhibiting delayed hypersensitivity or sera containing precipitating antibody did not sensitize normal cells to antigen.

4. The inhibition still occurs when heat-in-activated sera are used.

5. The findings are consistent with the view of the primary importance of cells in manifestations of delayed hypersensitivity reactions, and the in vitro system gives promise of further elucidation of the mechanism involved.

Footnotes

¹ Presented in part at the 47th Annual Meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 16 to 20, 1963.

Supported in part by a grant from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, AI-01254, and in part by the Streptococcal and Staphylococcal Disease Commission of the Armed Forces Epidemiological Board.

² Supported by United States Public Health Service Training Grant E.T.S. 2E-5.

³ Supported by Health Research Council of the City of New York, Contract U-1062.

⁴ United States Public Health Service Career Development Award GM-K3-15, 491-03.

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