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Serologic Studies of Embryonic and Trophoblastic Tissues of the Mouse¹

From the Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina

Abstract

The isoantigenicity of mouse embryonic and trophoblastic tissues was studied by quantitative absorptions of isohemagglutinins.

Isoantigenic activity was found in the earliest C3H embryos studied (10 days old). The antigenicity of the liver increased rapidly between days 13 and 15, whereafter it remained constant. In preterm embryos the thymus was the most antigenic organ, having an antigenicity similar to that of the adult thymus. The placenta showed a relatively high antigenicity which remained unchanged throughout pregnancy.

The livers of (129 x C3H) F₁ hybrids contained both paternal and maternal isoantigenic activity. The two antigens attained, at each developmental stage, about half the concentration found in homozygous embryos. Both the paternal and the maternal antigens were demonstrable in hybrid placentas.

No isoantigenic activity could be found in the trophoblastic growths resulting from grafts of 2- to 3-day-old fertilized C3H eggs into cryptorchid C57BL or 129 testes. It is concluded that the lack of H-2 isoantigenicity of the trophoblastic cells enables them to function as a barrier between the fetus and the mother.

Footnotes

¹ Presented in part at the second Rochester Trophoblast Conference, November 4 to 5, 1963.

² This investigation was supported by a Public Health Service International Postdoctoral Fellowship (FF-547).

Present address: Department of Experimental Medicine and Cancer Research, Hebrew University—Hadassah Medical School, Jerusalem, Israel.