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The Bactericidal Actions of O and VI Antibodies against Salmonella Typhosa¹

From the Department of Serology, Walter Reed Army Institute of Research, Washington, D. C. and the Department of Microbiology, University of Minnesota, Minneapolis, Minnesota

Abstract

Anti-Vi and anti-O are both bactericidal against virulent strains of S. typhosa. With currently used vaccines, however, the anti-Vi response contributed very little to the bactericidal action of immune serums. The bactericidal activity of such serums reflected primarily their anti-O content. The apparent lack of protection afforded by anti-Vi in human subjects may be related to this finding.

Footnotes

¹ A preliminary report of this work was presented at the 1961 Meeting of the American Association of Immunologists (1).