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Decreased Immunogenicity of a Transplantation Antigen in Hosts Sensitized to Other Isoantigens of its Cellular Vehicle¹

From the Wistar Institute of Anatomy and Biology and Harrison Department of Surgical Research, Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

1. Accelerated rejection of male skin isografts by C57BL/6 female mice occurs as a consequence of previous injection of 20 million male CBA spleen cells by either the i.p. or i.v. route.

2. However, if the test mice are immunized against CBA isoantigens from female donors 20 days before inoculation of the male CBA cells, rejection of the test grafts is significantly delayed.

3. The inhibitory effect of prior CBA isoimmunization on sensitization to the male factor does not occur when isologous male cells are mixed with CBA female spleen cells and inoculated.

4. These results are interpreted as evidence that the secondary response to the CBA isoantigens is capable of blocking access of the male antigen to those sites in which the primary response can be initiated.

Footnotes

¹ This work was supported by United States Public Health Service Training Grant 2G280 during 1961 and 1962, and by United States Public Health Service Grant C-5927 during 1962 and 1963.

² Present address: Tissue Bank Department, U. S. Naval Medical School, Bethesda, Maryland.