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Recall of Complement Fixing Antibodies to Enteroviruses in Guinea Pigs¹

From the Virus Laboratories at the Children's Hospital of Philadelphia and the School of Medicine, University of Pennsylvania

Abstract

The recall of complement-fixing antibodies was studied in guinea pigs previously immunized with one or several representative agents belonging to the poliomyelitis, Coxsackie A and B, and Echo groups. Although the studies were limited in scope, it became evident that poliomyelitis and Coxsackie B viruses readily recalled antibodies to the other members of the respective groups. Recalls were induced, although less frequently, by agents belonging to heterologous enterovirus groups but not by mumps virus. Antibodies were recalled often in the absence of detectable responses to the injected virus. A single dose of a given virus led to homologous antibody responses at an increased frequency if the animals had previous experience with another member of the same group of viruses. Broadening of the antibody spectra to include reactions with viruses not previously injected were observed only within the poliomyelitis group but the data are insufficient to exclude its occurrence among or between other groups of enteroviruses. Neutralization tests carried out with a few selected sera revealed that recalls of complementfixing antibodies were not accompanied by rises in neutralizing activity.

The results presented appear to parallel the experience gained in the serodiagnosis of enterovirus infections of man.

Footnotes

¹ The work described in this paper has been supported by Grants E-2405 and Training Grant 2E-104 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service.

² Present address: Universitäts Kinderklinik, Würzburg, Germany.