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Nonprecipitating Antibody and the Arthus Vasculitis¹

From the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

Abstract

The inability of two nonprecipitating antibodies to produce Arthus vascular inflammatory reactions was studied. In both cases the nonprecipitating antibody did not deposit antigen in the vessel walls in the form of an antigen-antibody-host complement complex, while relatively equal amounts of precipitating antibody did. Rabbit nonprecipitating antibody was found to interact with its antigen in the tissues equally as well as precipitating antibody (determined by passive cutaneous anaphylactic reactions) and was found abundantly capable of inactivating hemolytic guinea pig complement with components at least through C'3c taking part. It was proposed that heavy deposition of antigen-antibody complexes, perhaps with host complement, was essential for the accumulation of polymorphonuclear leukocytes and resulting vascular inflammatory damage.

Footnotes

¹ This work was supported by United States Public Health Service grants and an Atomic Energy Commission contract. This is publication number 51 from the Division of Experimental Pathology of the Scripps Clinic and Research Foundation.

² United States Public Health Service Post-Sophomore Research Fellow.

³ Helen Hay Whitney Foundation Fellow.